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MED8 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96G25
Clone Names 81202105
Peptide ID 81202105
Additional Information
Gene ID 112950
Other Names Mediator of RNA polymerase II transcription subunit 8, Activator-recruited cofactor 32 kDa component, ARC32, Mediator complex subunit 8, MED8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MED8
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
Cellular Location Nucleus.
Research Areas
Citations (0)

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This gene encodes a protein that is one of more than 20subunits of the mediator complex, first identified in S.cerevisiae, that is required for activation of transcription. Theproduct of this gene also interacts with elongins B and C, and CUL2and RBX1, to reconstitute a ubiquitin ligase. Two alternativetranscripts encoding different isoforms have been described.


Leonard, V.H., et al. J. Virol. 80(19):9667-9675(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Sato, S., et al. Mol. Cell 14(5):685-691(2004)Tomomori-Sato, C., et al. J. Biol. Chem. 279(7):5846-5851(2004)Sato, S., et al. J. Biol. Chem. 278(50):49671-49674(2003)

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$ 80.00
Cat# BP12649c
(40 western blots)
Availability: In Stock
Bulk Size
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