|Other Names||Mediator of RNA polymerase II transcription subunit 8, Activator-recruited cofactor 32 kDa component, ARC32, Mediator complex subunit 8, MED8|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|
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This gene encodes a protein that is one of more than 20subunits of the mediator complex, first identified in S.cerevisiae, that is required for activation of transcription. Theproduct of this gene also interacts with elongins B and C, and CUL2and RBX1, to reconstitute a ubiquitin ligase. Two alternativetranscripts encoding different isoforms have been described.
Leonard, V.H., et al. J. Virol. 80(19):9667-9675(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Sato, S., et al. Mol. Cell 14(5):685-691(2004)Tomomori-Sato, C., et al. J. Biol. Chem. 279(7):5846-5851(2004)Sato, S., et al. J. Biol. Chem. 278(50):49671-49674(2003)
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