|Other Names||Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, CD119, IFNGR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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This gene (IFNGR1) encodes the ligand-binding chain(alpha) of the gamma interferon receptor. Human interferon-gammareceptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variationin IFNGR1 is associated with susceptibility to Helicobacter pyloriinfection. In addition, defects in IFNGR1 are a cause of mendeliansusceptibility to mycobacterial disease, also known as familialdisseminated atypical mycobacterial infection. [provided byRefSeq].
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)de Wit, E., et al. Mamm. Genome (2010) In press :
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