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IREB2 Antibody (Center) Blocking PeptidesSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP12657c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
IREB2 Antibody (Center) Blocking Peptides - Product info | |
| Primary Accession | P48200 |
| Clone Names | 100318039 |
| Calculated MW | 105045 Da |
IREB2 Antibody (Center) Blocking Peptides - Additional info | |
| Gene ID 3658 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
IREB2 Antibody (Center) Blocking Peptides - Protein Information | |
| Name IREB2 | |
| Function RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA | |
| Cellular Location Cytoplasm. | |
IREB2 Antibody (Center) Blocking Peptides - Research Areas
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BACKGROUND
IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
REFERENCES
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Hansen, H.M., et al. Hum. Mol. Genet. 19(18):3652-3661(2010)Cho, M.H., et al. Nat. Genet. 42(3):200-202(2010)Salahudeen, A.A., et al. Science 326(5953):722-726(2009)DeMeo, D.L., et al. Am. J. Hum. Genet. 85(4):493-502(2009)
