|Other Names||Retrotransposon-derived protein PEG10, Embryonal carcinoma differentiation-regulated protein, Mammalian retrotransposon-derived protein 2, Myelin expression factor 3-like protein 1, MEF3-like protein 1, Paternally expressed gene 10 protein, Retrotransposon gag domain-containing protein 3, Retrotransposon-derived gag-like polyprotein, Ty3/Gypsy-like protein, PEG10, EDR, KIAA1051, MAR2, MART2, MEF3L1, RGAG3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||EDR, KIAA1051, MAR2, MART2, MEF3L1, RGAG|
|Function||Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1|
|Tissue Location||Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC).|
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This is a paternally expressed imprinted gene that encodestranscripts containing two overlapping open reading frames (ORFs),RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknotelements, which can induce a -1 nucleotide frame-shift. ORF1encodes a shorter isoform with a CCHC-type zinc finger motifcontaining a sequence characteristic of gag proteins of mostretroviruses and some retrotransposons. The longer isoform is theresult of -1 translational frame-shifting leading to translation ofa gag/pol-like protein combining RF1 and RF2. It contains theactive-site consensus sequence of the protease domain of polproteins. Additional isoforms resulting from alternatively splicedtranscript variants, as well as from use of upstream non-AUG (CUG)start codon, have been reported for this gene. Increased expressionof this gene is associated with hepatocellular carcinomas.
Tsuji, K., et al. Cancer Genet. Cytogenet. 198(2):118-125(2010)Chang, Y., et al. Zhonghua Gan Zang Bing Za Zhi 18(4):288-291(2010)Lux, H., et al. PLoS ONE 5 (1), E8686 (2010) :Wang, C., et al. FEBS Lett. 582(18):2793-2798(2008)Lux, A., et al. J. Biol. Chem. 280(9):8482-8493(2005)
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