|Other Names||Tenomodulin, TeM, hTeM, Chondromodulin-1-like protein, ChM1L, hChM1L, Chondromodulin-I-like protein, Myodulin, Tendin, TNMD, CHM1L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be an angiogenesis inhibitor.|
|Cellular Location||Isoform 1: Membrane; Single- pass type II membrane protein. Nucleus envelope Isoform 3: Cytoplasm.|
|Tissue Location||Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.|
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This gene encodes a protein that is related tochondromodulin-I, which is a cartilage-specific glycoprotein thatfunctions to stimulate chondrocyte growth and to inhibit tubeformation of endothelial cells. This protein is also anangiogenesis inhibitor. Genetic variation in this gene isassociated with a risk for type 2 diabetes, central obesity andserum levels of systemic immune mediators in a body size-dependentmanner. This gene is also a candidate gene for age-related maculardegeneration, though a direct link has yet to be demonstrated.
Saiki, A., et al. J. Clin. Endocrinol. Metab. 94(10):3987-3994(2009)Tolppanen, A.M., et al. Neurobiol. Aging (2009) In press :Tolppanen, A.M., et al. Mol. Vis. 15, 762-770 (2009) :Tolppanen, A.M., et al. Int J Obes (Lond) 32(12):1868-1872(2008)Kimura, N., et al. Circulation 118(17):1737-1747(2008)
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