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SKA2 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8WVK7
Clone Names 91201194
Peptide ID 91201194
Additional Information
Gene ID 348235
Other Names Spindle and kinetochore-associated protein 2, Protein FAM33A, SKA2, FAM33A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SKA2
Synonyms FAM33A
Function Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization.
Cellular Location Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins
Research Areas
Citations (0)

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Background

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization.

References

Cao, G., et al. Biochem. Biophys. Res. Commun. 396(4):978-982(2010)Welburn, J.P., et al. Dev. Cell 16(3):374-385(2009)Rice, L., et al. J. Endocrinol. 198(3):499-509(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Hanisch, A., et al. EMBO J. 25(23):5504-5515(2006)

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$ 80.00
Cat# BP12680a
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