|Other Names||Glutaredoxin domain-containing cysteine-rich protein 1, GRXCR1, DFNB25|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in actin filament architecture in developing stereocilia of sensory cells.|
|Cellular Location||Cell projection, stereocilium. Cell projection, microvillus. Cell projection, kinocilium. Note=In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia|
|Tissue Location||Expressed at low levels in adult lung, brain and duodenum with moderate levels in testis. Highly expressed in fetal cochlea.|
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This gene is one of 60 loci associated withautosomal-recessive nonsyndromic hearing impairment. This geneencodes a protein which contains GRX-like domains; these domainsplay a role in the S-glutathionylation of proteins and may beinvolved in actin organization in hair cells.
Schraders, M., et al. Am. J. Hum. Genet. 86(2):138-147(2010)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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