Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
STAMBP Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95630 |
|---|---|
| Clone Names | 100318055 |
| Gene ID | 10617 |
|---|---|
| Other Names | STAM-binding protein, 3419-, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, STAMBP, AMSH |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | STAMBP |
|---|---|
| Synonyms | AMSH {ECO:0000303|PubMed:10383417} |
| Function | Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699). |
| Cellular Location | Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome |
| Tissue Location | Ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Cytokine-mediated signal transduction in the JAK-STATcascade requires the involvement of adaptor molecules. One suchsignal-transducing adaptor molecule contains an SH3 domain that isrequired for induction of MYC and cell growth. The protein encodedby this gene binds to the SH3 domain of the signal-transducingadaptor molecule, and plays a critical role in cytokine-mediatedsignaling for MYC induction and cell cycle progression. Multiplealternatively spliced transcript variants encoding the same proteinisoform have been found for this gene.
References
Sierra, M.I., et al. J. Biol. Chem. 285(18):13990-14004(2010)Hasdemir, B., et al. J. Biol. Chem. 284(41):28453-28466(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Wang, P., et al. BMC Genomics 10, 518 (2009) :Sato, Y., et al. Nature 455(7211):358-362(2008)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
