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STAMBP Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O95630
Clone Names 100318055
Peptide ID 100318055
Additional Information
Gene ID 10617
Other Names STAM-binding protein, 3419-, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, STAMBP, AMSH
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms AMSH
Function Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Cellular Location Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Cytokine-mediated signal transduction in the JAK-STATcascade requires the involvement of adaptor molecules. One suchsignal-transducing adaptor molecule contains an SH3 domain that isrequired for induction of MYC and cell growth. The protein encodedby this gene binds to the SH3 domain of the signal-transducingadaptor molecule, and plays a critical role in cytokine-mediatedsignaling for MYC induction and cell cycle progression. Multiplealternatively spliced transcript variants encoding the same proteinisoform have been found for this gene.


Sierra, M.I., et al. J. Biol. Chem. 285(18):13990-14004(2010)Hasdemir, B., et al. J. Biol. Chem. 284(41):28453-28466(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Wang, P., et al. BMC Genomics 10, 518 (2009) :Sato, Y., et al. Nature 455(7211):358-362(2008)

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$ 80.00
Cat# BP12698b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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