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SF3B3 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q15393
Clone Names 100318120
Peptide ID 100318120
Additional Information
Gene ID 23450
Other Names Splicing factor 3B subunit 3, Pre-mRNA-splicing factor SF3b 130 kDa subunit, SF3b130, STAF130, Spliceosome-associated protein 130, SAP 130, SF3B3, KIAA0017, SAP130
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SF3B3
Synonyms KIAA0017, SAP130
Function Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Cellular Location Nucleus.
Research Areas
Citations (0)

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This gene encodes subunit 3 of the splicing factor 3bprotein complex. Splicing factor 3b, together with splicing factor3a and a 12S RNA unit, forms the U2 small nuclearribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3acomplex binds pre-mRNA upstream of the intron's branch site in asequence independent manner and may anchor the U2 snRNP to thepre-mRNA. Splicing factor 3b is also a component of the minorU12-type spliceosome. Subunit 3 has also been identified as acomponent of the STAGA (SPT3-TAF(II)31-GCN5L acetylase)transcription coactivator-HAT (histone acetyltransferase) complex,and the TFTC (TATA-binding-protein-free TAF(II)-containingcomplex). These complexes may function in chromatin modification,transcription, splicing, and DNA repair.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Will, C.L., et al. RNA 10(6):929-941(2004)Cavusoglu, N., et al. Proteomics 3(2):217-223(2003)Will, C.L., et al. EMBO J. 21(18):4978-4988(2002)Martinez, E., et al. Mol. Cell. Biol. 21(20):6782-6795(2001)

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$ 80.00
Cat# BP12703b
(40 western blots)
Availability: In Stock
Bulk Size
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