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SF3B3 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15393
Clone Names 100318120
Additional Information
Gene ID 23450
Other Names Splicing factor 3B subunit 3, Pre-mRNA-splicing factor SF3b 130 kDa subunit, SF3b130, STAF130, Spliceosome-associated protein 130, SAP 130, SF3B3, KIAA0017, SAP130
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SF3B3
Synonyms KIAA0017, SAP130 {ECO:0000303|PubMed:104
Function Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166, PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch- site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932).
Cellular Location Nucleus
Research Areas
Citations (0)
citation

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Background

This gene encodes subunit 3 of the splicing factor 3bprotein complex. Splicing factor 3b, together with splicing factor3a and a 12S RNA unit, forms the U2 small nuclearribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3acomplex binds pre-mRNA upstream of the intron's branch site in asequence independent manner and may anchor the U2 snRNP to thepre-mRNA. Splicing factor 3b is also a component of the minorU12-type spliceosome. Subunit 3 has also been identified as acomponent of the STAGA (SPT3-TAF(II)31-GCN5L acetylase)transcription coactivator-HAT (histone acetyltransferase) complex,and the TFTC (TATA-binding-protein-free TAF(II)-containingcomplex). These complexes may function in chromatin modification,transcription, splicing, and DNA repair.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Will, C.L., et al. RNA 10(6):929-941(2004)Cavusoglu, N., et al. Proteomics 3(2):217-223(2003)Will, C.L., et al. EMBO J. 21(18):4978-4988(2002)Martinez, E., et al. Mol. Cell. Biol. 21(20):6782-6795(2001)

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$ 277.78
Cat# BP12703b
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