|Other Names||Lysophosphatidic acid receptor 6, LPA receptor 6, LPA-6, Oleoyl-L-alpha-lysophosphatidic acid receptor, P2Y purinoceptor 5, P2Y5, Purinergic receptor 5, RB intron encoded G-protein coupled receptor, LPAR6, P2RY5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes|
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The protein encoded by this gene belongs to the family ofG-protein coupled receptors, that are preferentially activated byadenosine and uridine nucleotides. This gene aligns with aninternal intron of the retinoblastoma susceptibility gene in thereverse orientation. Alternative splicing results in multipletranscript variants.
Pasternack, S.M., et al. Arch. Dermatol. Res. 301(8):621-624(2009)Yanagida, K., et al. J. Biol. Chem. 284(26):17731-17741(2009)Tariq, M., et al. Br. J. Dermatol. 160(5):1006-1010(2009)Shimomura, Y., et al. J. Invest. Dermatol. 129(3):622-628(2009)Dereure, O. Ann Dermatol Venereol 135(11):794-795(2008)
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