|Other Names||Hepatocyte nuclear factor 6, HNF-6, One cut domain family member 1, One cut homeobox 1, ONECUT1, HNF6, HNF6A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.|
|Tissue Location||Highly expressed in liver; lower expression in testis and skin|
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Provided below are standard protocols that you may find useful for product applications.
ONECUT1 is a transcriptional activator. It binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. It is important for liver genes transcription.
Lee, Y.S., et al. Biochem. J. 413(3):559-569(2008)Jiang, X., et al. Oncol. Rep. 19(1):157-163(2008)Lehner, F., et al. FASEB J. 21(7):1445-1462(2007)Rausa, F.M. III, et al. J. Biol. Chem. 279(41):43070-43076(2004)Thomas, H., et al. Nucleic Acids Res. 32 (19), E150 (2004) :
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