|Other Names||Multivesicular body subunit 12B, ESCRT-I complex subunit MVB12B, Protein FAM125B, MVB12B, C9orf28, FAM125B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.|
|Cellular Location||Endosome. Late endosome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. FAM125B is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
Tsunematsu, T., et al. Biochem. Biophys. Res. Commun. 399(2):232-237(2010)Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :McClay, J.L., et al. Mol. Psychiatry (2009) In press :Morita, E., et al. Cell Host Microbe 2(1):41-53(2007)
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