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ABCG4 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H172
Clone Names 100324073
Additional Information
Gene ID 64137
Other Names ATP-binding cassette sub-family G member 4, ABCG4, WHITE2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCG4 (HGNC:13884)
Synonyms WHITE2
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (PubMed:27228027).
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi- pass membrane protein
Tissue Location Expressed specifically in the brain and the eye.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is included in thesuperfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinctsubfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). Thisprotein is a member of the White subfamily and is expressedpredominantly in liver tissue. The function has not yet beendetermined but may involve cholesterol transport. Alternate splicevariants have been described but their full length sequences havenot been determined.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Koshiba, S., et al. Xenobiotica 38 (7-8), 863-888 (2008) :

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$ 277.78
Cat# BP12723a
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