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ZP4 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q12836
Clone Names 100324075
Peptide ID 100324075
Additional Information
Gene ID 57829
Other Names Zona pellucida sperm-binding protein 4, Zona pellucida glycoprotein 4, Zp-4, Zona pellucida protein B, Processed zona pellucida sperm-binding protein 4, ZP4, ZPB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZP4
Synonyms ZPB
Function The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
Cellular Location Processed zona pellucida sperm-binding protein 4: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q00193}. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.
Tissue Location Oocytes.
Research Areas
Citations (0)

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The zona pellucida is an extracellular matrix thatsurrounds the oocyte and early embryo. It is composed primarily ofthree or four glycoproteins with various functions duringfertilization and preimplantation development. The nascent proteincontains a N-terminal signal peptide sequence, a conserved ZPdomain, a consensus furin cleavage site, and a C-terminaltransmembrane domain. It is hypothesized that furin cleavageresults in release of the mature protein from the plasma membranefor subsequent incorporation into the zona pellucida matrix.However, the requirement for furin cleavage in this process remainscontroversial based on mouse studies. Previously, this gene hasbeen referred to as ZP1 or ZPB and thought to have similarfunctions as mouse Zp1. However, a human gene with highersimilarity and chromosomal synteny to mouse Zp1 has been assignedthe symbol ZP1 and this gene has been assigned the symbol ZP4.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :McCauley, J.L., et al. Genes Immun. 10(7):624-630(2009)Nakano, M., et al. Proc. Natl. Acad. Sci. U.S.A. 106(31):12838-12842(2009)Choudhury, S., et al. J. Reprod. Immunol. 79(2):137-147(2009)Chiu, P.C., et al. Biol. Reprod. 79(5):869-877(2008)

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$ 80.00
Cat# BP12724b
(40 western blots)
Availability: In Stock
Bulk Size
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