|Other Names||G-protein-signaling modulator 1, Activator of G-protein signaling 3, GPSM1, AGS3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.|
|Cellular Location||Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in intestinal cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
G proteins propagate intracellular signals initiated by Gprotein-coupled receptors. GPSM1, a receptor-independent activatorof G protein signaling, is one of several factors that influencethe basal activity of G protein signaling systems (Pizzinat et al.,2001 [PubMed 11278352]).
Oner, S.S., et al. J. Biol. Chem. 285(44):33949-33958(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Vural, A., et al. Mol. Cell. Biol. 30(6):1528-1540(2010)Groves, B., et al. PLoS ONE 5 (1), E8877 (2010) :An, N., et al. J. Biol. Chem. 283(36):24718-24728(2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.