GPSM1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86YR5 |
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Clone Names | 100324149 |
Gene ID | 26086 |
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Other Names | G-protein-signaling modulator 1, Activator of G-protein signaling 3, GPSM1, AGS3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GPSM1 |
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Synonyms | AGS3 |
Function | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein- coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. |
Cellular Location | Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side |
Tissue Location | Expressed in intestinal cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
G proteins propagate intracellular signals initiated by Gprotein-coupled receptors. GPSM1, a receptor-independent activatorof G protein signaling, is one of several factors that influencethe basal activity of G protein signaling systems (Pizzinat et al.,2001 [PubMed 11278352]).
References
Oner, S.S., et al. J. Biol. Chem. 285(44):33949-33958(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Vural, A., et al. Mol. Cell. Biol. 30(6):1528-1540(2010)Groves, B., et al. PLoS ONE 5 (1), E8877 (2010) :An, N., et al. J. Biol. Chem. 283(36):24718-24728(2008)
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