|Other Names||Sodium/potassium-transporting ATPase subunit beta-3, Sodium/potassium-dependent ATPase subunit beta-3, ATPB-3, CD298, ATP1B3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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The protein encoded by this gene belongs to the family ofNa+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamilyof Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane proteinresponsible for establishing and maintaining the electrochemicalgradients of Na and K ions across the plasma membrane. Thesegradients are essential for osmoregulation, for sodium-coupledtransport of a variety of organic and inorganic molecules, and forelectrical excitability of nerve and muscle. This enzyme iscomposed of two subunits, a large catalytic subunit (alpha) and asmaller glycoprotein subunit (beta). The beta subunit regulates,through assembly of alpha/beta heterodimers, the number of sodiumpumps transported to the plasma membrane. The glycoprotein subunitof Na+/K+ -ATPase is encoded by multiple genes. This gene encodes abeta 3 subunit. This gene encodes a beta 3 subunit. A pseudogeneexists for this gene, and it is located on chromosome 2. [providedby RefSeq].
Floyd, R.V., et al. Reprod Sci 17(4):366-376(2010)Aughey, R.J., et al. J. Appl. Physiol. 103(1):39-47(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Chiampanichayakul, S., et al. Tissue Antigens 68(6):509-517(2006)Chi, A., et al. J. Proteome Res. 5(11):3135-3144(2006)
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