|Other Names||cTAGE family member 5, Protein cTAGE-5, Meningioma-expressed antigen 6/11, CTAGE5, MEA11, MEA6, MGEA11, MGEA6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Endoplasmic reticulum exit sites|
|Tissue Location||Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T- cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma|
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Provided below are standard protocols that you may find useful for product applications.
CTAGE5 is a tumor-associated antigen.
Wu, C., et al. Proteomics 7(11):1775-1785(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Usener, D., et al. J. Invest. Dermatol. 121(1):198-206(2003)Comtesse, N., et al. Oncogene 21(2):239-247(2002)
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