|Other Names||Actin filament-associated protein 1, 110 kDa actin filament-associated protein, AFAP-110, AFAP1, AFAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.|
|Cellular Location||Cytoplasm, cytoskeleton. Note=Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction|
|Tissue Location||Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF- 7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.|
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The protein encoded by this gene is a Src binding partner.It may represent a potential modulator of actin filament integrityin response to cellular signals, and may function as an adaptorprotein by linking Src family members and/or other signalingproteins to actin filaments. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Dorfleutner, A., et al. J. Cell. Physiol. 213(3):740-749(2007)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)Qian, Y., et al. J. Cell. Biochem. 91(3):602-620(2004)Qian, Y., et al. Mol. Biol. Cell 13(7):2311-2322(2002)Baisden, J.M., et al. Oncogene 20(45):6607-6616(2001)
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