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TPM4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P67936 |
|---|---|
| Clone Names | 101008244 |
| Gene ID | 7171 |
|---|---|
| Other Names | Tropomyosin alpha-4 chain, TM30p1, Tropomyosin-4, TPM4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TPM4 |
|---|---|
| Function | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P09495}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P09495} |
| Tissue Location | Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the tropomyosin family ofactin-binding proteins involved in the contractile system ofstriated and smooth muscles and the cytoskeleton of non-musclecells. Tropomyosins are dimers of coiled-coil proteins thatpolymerize end-to-end along the major groove in most actinfilaments. They provide stability to the filaments and regulateaccess of other actin-binding proteins. In muscle cells, theyregulate muscle contraction by controlling the binding of myosinheads to the actin filament. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
References
Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)Vlahovich, N., et al. Cell Motil. Cytoskeleton 65(1):73-85(2008)Montesano Gesualdi, N., et al. Free Radic. Res. 40(5):467-476(2006)Hossain, M.M., et al. J. Biol. Chem. 280(51):42442-42453(2005)Bruneel, A., et al. Proteomics 5(15):3876-3884(2005)
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