|Other Names||Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1, WHSC1L1, NSD3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.|
|Cellular Location||Nucleus. Chromosome|
|Tissue Location||Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung|
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This gene is related to the Wolf-Hirschhorn syndromecandidate-1 gene and encodes a protein with PWWP(proline-tryptophan-tryptophan-proline) domains. The function ofthe protein has not been determined. Two alternatively splicedvariants have been described.
Zhou, Z., et al. Biochem. Biophys. Res. Commun. 398(3):565-570(2010)Kim, S.M., et al. Biochem. Biophys. Res. Commun. 345(1):318-323(2006)Tonon, G., et al. Proc. Natl. Acad. Sci. U.S.A. 102(27):9625-9630(2005)Rosati, R., et al. Blood 99(10):3857-3860(2002)Stec, I., et al. Genomics 76 (1-3), 5-8 (2001) :
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