|Other Names||Borealin, Cell division cycle-associated protein 8, Dasra-B, hDasra-B, Pluripotent embryonic stem cell-related gene 3 protein, CDCA8, PESCRG3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.|
|Cellular Location||Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells|
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Provided below are standard protocols that you may find useful for product applications.
CDCA8 is a component of a chromosomal passenger complexrequired for stability of the bipolar mitotic spindle (Gassmann etal., 2004 [PubMed 15249581]).
Bourhis, E., et al. Biochemistry 48(29):6783-6793(2009)Zhang, Q., et al. Mol. Biol. Rep. 36(3):603-609(2009)Klein, U.R., et al. Mol. Biol. Cell 20(1):410-418(2009)Xia, F., et al. Mol. Cell. Biol. 28(17):5299-5311(2008)Jelluma, N., et al. Cell 132(2):233-246(2008)
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