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ELF4 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q99607
Clone Names 81006113
Peptide ID 81006113
Additional Information
Gene ID 2000
Other Names ETS-related transcription factor Elf-4, E74-like factor 4, Myeloid Elf-1-like factor, ELF4 {ECO:0000312|EMBL:CAI428821}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELF4 {ECO:0000312|EMBL:CAI42882.1}
Function Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
Cellular Location Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML
Tissue Location Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain
Research Areas
Citations (0)

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The protein encoded by this gene is a transcriptionalactivator that binds and activates the promoters of the CSF2, IL3,IL8, and PRF1 genes. The encoded protein is involved in naturalkiller cell development and function, innate immunity, andinduction of cell cycle arrest in naive CD8+ cells. Two transcriptvariants encoding the same protein have been found for this gene.


Yamada, T., et al. Nat. Immunol. 10(6):618-626(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Moore, S.D., et al. Leuk. Res. 30(8):1037-1042(2006)Liu, Y., et al. Mol. Cell. Biol. 26(8):3114-3123(2006)Koga, T., et al. FEBS Lett. 579(13):2811-2816(2005)

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$ 80.00
Cat# BP12761a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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