|Other Names||Speckle-type POZ protein-like, HIB homolog 2, Roadkill homolog 2, SPOPL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.|
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Provided below are standard protocols that you may find useful for product applications.
In complex with a cullin, may act in ubiquitination and proteasomal degradation processes (By similarity).
Lamesch, P., et al. Genomics 89(3):307-315(2007)Zhang, Q., et al. Dev. Cell 10(6):719-729(2006)Kent, D., et al. Development 133(10):2001-2010(2006)
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