|Other Names||Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4, 11411-, Alkylated DNA repair protein alkB homolog 4, ALKBH4, ABH4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.|
|Cellular Location||Cytoplasm. Nucleus. Midbody. Note=Associates with the contractile ring and midbody|
|Tissue Location||Widely expressed, with highest expression in pancreas, ovary and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
Tsujikawa, K., et al. J. Cell. Mol. Med. 11(5):1105-1116(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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