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XYLT1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86Y38 |
|---|---|
| Clone Names | 100318136 |
| Gene ID | 64131 |
|---|---|
| Other Names | Xylosyltransferase 1, Peptide O-xylosyltransferase 1, Xylosyltransferase I, XT-I, XylT-I, XYLT1, XT1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | XYLT1 |
|---|---|
| Synonyms | XT1 |
| Function | Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D- xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343). Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343). Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity). |
| Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Secreted Note=Detected predominantly in the Golgi apparatus |
| Tissue Location | Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This locus encodes a xylosyltransferase enzyme. Theencoded protein catalyzes transfer of UDP-xylose to serine residuesof an acceptor protein substrate. This transfer reaction isnecessary for biosynthesis of glycosaminoglycan chains. Mutationsin this gene have been associated with increased severity ofpseudoxanthoma elasticum.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Muller, B., et al. J. Biol. Chem. 284(45):30775-30782(2009)Ponighaus, C., et al. Am. J. Hypertens. 22(4):432-436(2009)Ambrosius, M., et al. Clin. Biochem. 42 (1-2), 1-4 (2009) :Schon, S., et al. J. Med. Genet. 43(9):745-749(2006)
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