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SHANK2 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UPX8
Clone Names 100318149
Peptide ID 100318149
Additional Information
Gene ID 22941
Other Names SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, Proline-rich synapse-associated protein 1, SHANK2, CORTBP1, KIAA1022, PROSAP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHANK2
Synonyms CORTBP1, KIAA1022, PROSAP1
Function Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Cellular Location Apical cell membrane. Cytoplasm. Cell junction, synapse Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, growth cone Cell projection, dendritic spine. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity).
Tissue Location Isoform 3 is present in epithelial colonic cells (at protein level).
Research Areas
Citations (0)

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Background

This gene encodes a protein that is a member of the Shankfamily of synaptic proteins that may function as molecularscaffolds in the postsynaptic density (PSD). Shank proteins containmultiple domains for protein-protein interaction, including ankyrinrepeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alphamotif domain, and a proline-rich region. This particular familymember contains a PDZ domain, a consensus sequence for cortactinSH3 domain-binding peptides and a sterile alpha motif. Thealternative splicing demonstrated in Shank genes has been suggestedas a mechanism for regulating the molecular structure of Shank andthe spectrum of Shank-interacting proteins in the PSDs of adult anddeveloping brain. Two alternative splice variants, encodingdistinct isoforms, are reported. Additional splice variants existbut their full-length nature has not been determined. [provided byRefSeq].

References

Pinto, D., et al. Nature 466(7304):368-372(2010)Berkel, S., et al. Nat. Genet. 42(6):489-491(2010)Lee, J.S., et al. J. Biol. Chem. 285(11):8104-8113(2010)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 80.00
Cat# BP12783c
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