|Other Names||ATP-dependent RNA helicase DDX3Y, DEAD box protein 3, Y-chromosomal, DDX3Y, DBY|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.|
|Cellular Location||Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner|
|Tissue Location||Testis-specific. Expressed predominantly in spermatogonia.|
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DEAD box proteins, characterized by the conserved motifAsp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alterationof RNA secondary structure such as translation initiation, nuclearand mitochondrial splicing, and ribosome and spliceosome assembly.Based on their distribution patterns, some members of this familyare believed to be involved in embryogenesis, spermatogenesis, andcellular growth and division. This gene encodes a DEAD box protein,and it has a homolog on the X chromosome. The gene mutation causesmale infertility, Sertoli cell-only syndrome or severehypospermatogenesis, suggesting that this gene plays a key role inthe spermatogenic process. Alternatively spliced variants, encodingthe same protein, have been identified.
Rosinski, K.V., et al. Blood 111(9):4817-4826(2008)Lardone, M.C., et al. Mol. Hum. Reprod. 13(10):705-712(2007)Pope, S.N., et al. J. Steroid Biochem. Mol. Biol. 94 (1-3), 203-208 (2005) :Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Ficarro, S.B., et al. Rapid Commun. Mass Spectrom. 19(1):57-71(2005)
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