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TRUB1 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8WWH5
Clone Names 91201302
Additional Information
Gene ID 142940
Other Names Probable tRNA pseudouridine synthase 1, 5499-, TRUB1, PUS4
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRUB1 {ECO:0000303|PubMed:12736709, ECO:0000312|HGNC:HGNC:16060}
Function Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'- GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri- let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445).
Cellular Location Nucleus. Cytoplasm, cytosol. Note=Catalyzes pseudouridylation of mRNAs in the nucleus.
Tissue Location Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small intestine, kidney and spleen.
Research Areas
Citations (0)
citation

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Background

Pseudouridine is an abundant component of rRNAs and tRNAsand is enzymatically generated by isomerization of uridine bypseudouridine synthase (Zucchini et al., 2003 [PubMed12736709]).

References

Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Deloukas, P., et al. Nature 429(6990):375-381(2004)Zucchini, C., et al. Int. J. Mol. Med. 11(6):697-704(2003)

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$ 277.78
Cat# BP12789c
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