|Other Names||NF-kappa-B inhibitor-like protein 1, Inhibitor of kappa B-like protein, I-kappa-B-like protein, IkappaBL, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1, NFKBIL1, IKBL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.|
|Cellular Location||Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus|
|Tissue Location||Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes|
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This gene encodes a divergent member of the I-kappa-Bfamily of proteins. Its function has not been determined. The genelies within the major histocompatibility complex (MHC) class Iregion on chromosome 6. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Clancy, R.M., et al. Arthritis Rheum. 62(11):3415-3424(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Owecki, M.K., et al. Pol. Merkur. Lekarski 28(167):366-370(2010)
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