|Other Names||GTPase RhebL1, Ras homolog enriched in brain like-1 c, RhebL1c, Ras homolog enriched in brain-like protein 1, Rheb-like protein 1, Rheb2, RHEBL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.|
|Cellular Location||Endomembrane system; Lipid-anchor; Cytoplasmic side Cytoplasm|
|Tissue Location||Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines|
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RHEBL1 binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through FRAP1, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
Yuan, J., et al. Mol. Biol. Rep. 32(4):205-214(2005)Tee, A.R., et al. FEBS Lett. 579(21):4763-4768(2005)Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)Tabancay, A.P. Jr., et al. J. Biol. Chem. 278(41):39921-39930(2003)
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