|Other Names||Sodium/calcium exchanger 3, Na(+)/Ca(2+)-exchange protein 3, Solute carrier family 8 member 3, SLC8A3, NCX3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle|
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This gene encodes a member of the sodium/calcium exchangerintegral membrane protein family. Three mammalian isoforms infamily 8 have been identified. Na+/Ca2+ exchange proteins areinvolved in maintaining Ca2+ homeostasis in a wide variety of celltypes. The protein is regulated by intracellular calcium ions andis found in both the plasma membrane and intracellular organellarmembranes, where exchange of Na+ for Ca2+ occurs in an electrogenicmanner. Alternative splicing has been observed for this gene andmultiple variants have been described.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Pulina, M.V., et al. J. Biol. Chem. 281(28):19645-19654(2006)Gomez-Villafuertes, R., et al. J. Neurosci. 25(47):10822-10830(2005)Lindgren, R.M., et al. Gene 348, 143-155 (2005) :Gabellini, N. Mol. Neurobiol. 30(1):91-116(2004)
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