TNP2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q05952 |
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Clone Names | 100324076 |
Gene ID | 7142 |
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Other Names | Nuclear transition protein 2, TP-2, TP2, TNP2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TNP2 |
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Function | Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P11101}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P11101}. Chromosome {ECO:0000250|UniProtKB:P11101}. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity). {ECO:0000250|UniProtKB:P11101, ECO:0000250|UniProtKB:P11378} |
Tissue Location | Expressed by spermatids (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.
References
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)Khattri, A., et al. Int. J. Androl. (2010) In press :Pradeepa, M.M., et al. J. Biol. Chem. 284(43):29956-29967(2009)Cooper, J.D., et al. Nat. Genet. 40(12):1399-1401(2008)Becker, S., et al. Andrologia 40(4):203-208(2008)
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