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TNP2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q05952
Clone Names 100324076
Additional Information
Gene ID 7142
Other Names Nuclear transition protein 2, TP-2, TP2, TNP2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNP2
Function Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Cellular Location Nucleus {ECO:0000250|UniProtKB:P11101}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P11101}. Chromosome {ECO:0000250|UniProtKB:P11101}. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity). {ECO:0000250|UniProtKB:P11101, ECO:0000250|UniProtKB:P11378}
Tissue Location Expressed by spermatids (at protein level).
Research Areas
Citations (0)
citation

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Background

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

References

Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)Khattri, A., et al. Int. J. Androl. (2010) In press :Pradeepa, M.M., et al. J. Biol. Chem. 284(43):29956-29967(2009)Cooper, J.D., et al. Nat. Genet. 40(12):1399-1401(2008)Becker, S., et al. Andrologia 40(4):203-208(2008)

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$ 277.78
Cat# BP12809b
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