|Other Names||Brain mitochondrial carrier protein 1, BMCP-1, Mitochondrial uncoupling protein 5, UCP 5, Solute carrier family 25 member 14, SLC25A14, BMCP1, UCP5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the mitochondrial proton leak measured in brain mitochondria.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
|Tissue Location||Mainly expressed in brain. Some expression in testis and pituitary.|
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Provided below are standard protocols that you may find useful for product applications.
Mitochondrial uncoupling proteins (UCP) are members of thelarger family of mitochondrial anion carrier proteins (MACP). UCPsseparate oxidative phosphorylation from ATP synthesis with energydissipated as heat, also referred to as the mitochondrial protonleak. UCPs facilitate the transfer of anions from the inner to theouter mitochondrial membrane and the return transfer of protonsfrom the outer to the inner mitochondrial membrane. They alsoreduce the mitochondrial membrane potential in mammalian cells.Tissue specificity occurs for the different UCPs and the exactmethods of how UCPs transfer H+/OH- are not known. UCPs contain thethree homologous protein domains of MACPs. This gene is widelyexpressed in many tissues with the greatest abundance in brain andtestis. The gene product has an N-terminal hydrophobic domain thatis not present in other UCPs. Two splice variants have been foundfor this gene.
Santandreu, F.M., et al. Cell. Physiol. Biochem. 24 (5-6), 379-390 (2009) :Nakase, T., et al. Neuropathology 27(5):442-447(2007)Yasuno, K., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (2), 250-253 (2007) :Ho, P.W., et al. J. Neurosci. Res. 84(6):1358-1366(2006)Ross, M.T., et al. Nature 434(7031):325-337(2005)
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