|Other Names||E3 ubiquitin-protein ligase RNF38, 632-, RING finger protein 38, RNF38|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.|
|Tissue Location||Widely expressed with highest levels in testis.|
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This gene encodes a protein with a coiled-coil motif and aRING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is azinc-binding domain found in a large set of proteins playing rolesin diverse cellular processes including oncogenesis, development,signal transduction, and apoptosis. Multiple transcript variantsencoding different isoforms have been found for this gene.
Humphray, S.J., et al. Nature 429(6990):369-374(2004)Eisenberg, I., et al. Biochem. Biophys. Res. Commun. 294(5):1169-1176(2002)
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