SLC13A2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q13183 |
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Clone Names | 100324281 |
Gene ID | 9058 |
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Other Names | Solute carrier family 13 member 2, Na(+)/dicarboxylate cotransporter 1, NaDC-1, Renal sodium/dicarboxylate cotransporter, SLC13A2, NADC1, SDCT1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC13A2 |
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Synonyms | NADC1, SDCT1 |
Function | Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:9668069, PubMed:8967342). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:8967342, PubMed:9668069, PubMed:10894787). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:10894787). Has a critical role in renal dicarboxylate transport (By similarity). |
Cellular Location | Apical cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in kidney and intestine (PubMed:8967342). In kidney expressed in the proximal tubule (at protein level) (PubMed:27927654). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cotransport of sodium ions and dicarboxylates such as succinate and citrate.
References
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Weerachayaphorn, J., et al. Biochemistry 47(3):1087-1093(2008)Okamoto, N., et al. Int. J. Urol. 14(4):344-349(2007)Pajor, A.M. Pflugers Arch. 451(5):597-605(2006)Pajor, A.M., et al. J. Biol. Chem. 280(19):18728-18735(2005)
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