|Other Names||Sperm mitochondrial-associated cysteine-rich protein, SMCP, MCS, MCSP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).|
|Cellular Location||Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis|
|Tissue Location||Testis. Is selectively expressed in the spermatids of seminiferous tubules.|
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Provided below are standard protocols that you may find useful for product applications.
Sperm mitochondria differ in morphology and subcellularlocalization from those of somatic cells. They are elongated,flattened, and arranged circumferentially to form a helical coiledsheath in the midpiece of the sperm flagellum. The protein encodedby this gene localizes to the capsule associated with themitochondrial outer membranes and is thought to function in theorganization and stabilization of the helical structure of thesperm's mitochondrial sheath.
Yatsenko, A.N., et al. Hum. Mol. Genet. 15(23):3411-3419(2006)Hawthorne, S.K., et al. Genomics 87(3):382-391(2006)Behne, D., et al. Annu. Rev. Nutr. 21, 453-473 (2001) :Cataldo, L., et al. Mol. Reprod. Dev. 45(3):320-331(1996)Aho, H., et al. Genomics 32(2):184-190(1996)
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