|Other Accession||NP_963886.1, NP_005268.1, NP_963885.1|
|Other Names||Neuronal membrane glycoprotein M6-a, M6a, GPM6A, M6A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendritic spine Cell projection, filopodium. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Morrison, A.C., et al. Circ Cardiovasc Genet 3(3):248-255(2010)Rose, J. Phd, et al. Mol. Med. (2010) In press :Michibata, H., et al. Stem Cells Dev. 18(4):629-639(2009)Boks, M.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 707-711 (2008) :Liang, Y.J., et al. Cell Res. 18(7):768-779(2008)
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