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PUS1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y606
Clone Names 100405129
Additional Information
Gene ID 80324
Other Names tRNA pseudouridine synthase A, mitochondrial, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I, PUS1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PUS1 {ECO:0000303|PubMed:17056637, ECO:0000312|HGNC:HGNC:15508}
Function Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:15772074, PubMed:24722331). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:24722331). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:24722331).
Cellular Location [Isoform 1]: Mitochondrion
Tissue Location Widely expressed (PubMed:15108122). High levels of expression found in brain and skeletal muscle (PubMed:15108122)
Research Areas
Citations (0)
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Background

This gene encodes a pseudouridine synthase that convertsuridine to pseudouridine once it has been incorporated into an RNAmolecule. The encoded enzyme may play an essential role in tRNAfunction and in stabilizing the secondary and tertiary structure ofmany RNAs. A mutation in this gene has been linked to mitochondrialmyopathy and sideroblastic anemia. Alternate splicing results inmultiple transcript variants.

References

Bergmann, A.K., et al. Pediatr Blood Cancer 54(2):273-278(2010)Sibert, B.S., et al. RNA 14(9):1895-1906(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Fernandez-Vizarra, E., et al. J. Med. Genet. 44(3):173-180(2007)

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$ 277.78
Cat# BP12835b
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