PUS1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y606 |
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Clone Names | 100405129 |
Gene ID | 80324 |
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Other Names | tRNA pseudouridine synthase A, mitochondrial, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I, PUS1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PUS1 {ECO:0000303|PubMed:17056637, ECO:0000312|HGNC:HGNC:15508} |
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Function | Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:15772074, PubMed:24722331). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:24722331). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:24722331). |
Cellular Location | [Isoform 1]: Mitochondrion |
Tissue Location | Widely expressed (PubMed:15108122). High levels of expression found in brain and skeletal muscle (PubMed:15108122) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a pseudouridine synthase that convertsuridine to pseudouridine once it has been incorporated into an RNAmolecule. The encoded enzyme may play an essential role in tRNAfunction and in stabilizing the secondary and tertiary structure ofmany RNAs. A mutation in this gene has been linked to mitochondrialmyopathy and sideroblastic anemia. Alternate splicing results inmultiple transcript variants.
References
Bergmann, A.K., et al. Pediatr Blood Cancer 54(2):273-278(2010)Sibert, B.S., et al. RNA 14(9):1895-1906(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Fernandez-Vizarra, E., et al. J. Med. Genet. 44(3):173-180(2007)
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