|Other Names||Lysyl oxidase homolog 3, 143-, Lysyl oxidase-like protein 3, LOXL3, LOXL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Both isoforms function as amine oxidases toward elastin and different types of collagens. Isoform 1 shows the highest activity toward collagen type VIII, while Isoform 2 presents the highest activity toward collagen type IV.|
|Cellular Location||Isoform 1: Secreted, extracellular space|
|Tissue Location||Isoform 1 ia predominantly detected in the heart, placenta, lung, and small intestine, while isoform 2 is more highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung.|
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This gene encodes a member of the lysyl oxidase genefamily. The prototypic member of the family is essential to thebiogenesis of connective tissue, encoding an extracellularcopper-dependent amine oxidase that catalyses the first step in theformation of crosslinks in collagens and elastin. A highlyconserved amino acid sequence at the C-terminus end appears to besufficient for amine oxidase activity, suggesting that each familymember may retain this function. The N-terminus is poorly conservedand may impart additional roles in developmental regulation,senescence, tumor suppression, cell growth control, and chemotaxisto each member of the family. Alternatively spliced transcriptvariants of this gene have been reported but their full-lengthnature has not been determined.
Kim, Y., et al. Oncol. Rep. 22(4):799-804(2009)Sebban, S., et al. Virchows Arch. 454(1):71-79(2009)Akagawa, H., et al. Hum. Genet. 121 (3-4), 377-387 (2007) :Lee, J.E., et al. J. Biol. Chem. 281(49):37282-37290(2006)Peinado, H., et al. EMBO J. 24(19):3446-3458(2005)
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