|Other Names||Double C2-like domain-containing protein alpha, Doc2, Doc2-alpha, DOC2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.|
|Cellular Location||Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles|
|Tissue Location||Predominantly expressed in brain. Also expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
There are at least two protein isoforms of the Double C2protein, namely alpha (DOC2A) and beta (DOC2B), which contain twoC2-like domains. DOC2A and DOC2B are encoded by different genes;these genes are at times confused with the unrelated DAB2 genewhich was initially named DOC-2. DOC2A is mainly expressed in brainand is suggested to be involved in Ca(2+)-dependentneurotransmitter release.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Glessner, J.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(23):10584-10589(2010)Guilmatre, A., et al. Arch. Gen. Psychiatry 66(9):947-956(2009)Kumar, R.A., et al. PLoS ONE 4 (2), E4582 (2009) :Higashio, H., et al. J. Immunol. 180(7):4774-4784(2008)
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