|Other Names||Carbohydrate sulfotransferase 8, 282-, GalNAc-4-O-sulfotransferase 1, GalNAc-4-ST1, GalNAc4ST-1, N-acetylgalactosamine-4-O-sulfotransferase 1, CHST8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Predominantly expressed in pituitary gland. In brain, it is expressed in pituitary gland, cerebellum, medulla oblongata, pons, thalamus and spinal cord. Expressed in the epidermis. Expressed at lower level in lung, spleen, adrenal gland, placenta, prostate, testis, mammary gland and trachea|
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Provided below are standard protocols that you may find useful for product applications.
Sulfate groups in carbohydrates confer highly specificfunctions on glycoproteins, glycolipids, and proteoglycans and arecritical for cell-cell interaction, signal transduction, andembryonic development. Sulfotransferases, such as CHST8, carry outsulfation of carbohydrates (Hiraoka et al., 2001 [PubMed11445554]).
Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009)Boregowda, R.K., et al. Glycobiology 15(12):1349-1358(2005)Barret, A., et al. J. Biol. Chem. 280(11):10516-10523(2005)
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