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CHST8 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H2A9
Clone Names 100405164
Additional Information
Gene ID 64377
Other Names Carbohydrate sulfotransferase 8, 282-, GalNAc-4-O-sulfotransferase 1, GalNAc-4-ST1, GalNAc4ST-1, N-acetylgalactosamine-4-O-sulfotransferase 1, CHST8
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHST8
Function Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.
Cellular Location Golgi apparatus membrane; Single- pass type II membrane protein
Tissue Location Predominantly expressed in pituitary gland. In brain, it is expressed in pituitary gland, cerebellum, medulla oblongata, pons, thalamus and spinal cord. Expressed in the epidermis Expressed at lower level in lung, spleen, adrenal gland, placenta, prostate, testis, mammary gland and trachea
Research Areas
Citations (0)
citation

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Background

Sulfate groups in carbohydrates confer highly specificfunctions on glycoproteins, glycolipids, and proteoglycans and arecritical for cell-cell interaction, signal transduction, andembryonic development. Sulfotransferases, such as CHST8, carry outsulfation of carbohydrates (Hiraoka et al., 2001 [PubMed11445554]).

References

Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009)Boregowda, R.K., et al. Glycobiology 15(12):1349-1358(2005)Barret, A., et al. J. Biol. Chem. 280(11):10516-10523(2005)

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$ 277.78
Cat# BP12842c
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