|Other Names||Histone H2B type 1-C/E/F/G/I, Histone H2B1 A, Histone H2Ba, H2B/a, Histone H2Bg, H2B/g, Histone H2Bh, H2B/h, Histone H2Bk, H2B/k, Histone H2Bl, H2B/l, HIST1H2BC, H2BFL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|
|Cellular Location||Nucleus. Chromosome.|
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Provided below are standard protocols that you may find useful for product applications.
Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene is intronless and encodes a member of thehistone H2B family. Transcripts from this gene lack polyA tails;instead, they contain a palindromic termination element. This geneis found in the large histone gene cluster on chromosome6p22-p21.3.
Kim, S.C., et al. Mol. Cell 23(4):607-618(2006)Beck, H.C., et al. Mol. Cell Proteomics 5(7):1314-1325(2006)Pavri, R., et al. Cell 125(4):703-717(2006)Bonenfant, D., et al. Mol. Cell Proteomics 5(3):541-552(2006)Siuti, N., et al. J. Proteome Res. 5(2):233-239(2006)
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