|Other Names||GDP-fucose protein O-fucosyltransferase 2, Peptide-O-fucosyltransferase 2, O-FucT-2, POFUT2, C21orf80, FUT13, KIAA0958|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C21orf80, FUT13, KIAA0958|
|Function||Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13.|
|Cellular Location||Endoplasmic reticulum. Golgi apparatus. Note=Mainly located in the endoplasmic reticulum|
|Tissue Location||Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart.|
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Provided below are standard protocols that you may find useful for product applications.
Fucose is typically found as a terminal modification ofbranched chain glycoconjugates, but it also exists in directO-linkage to serine or threonine residues within cystine knotmotifs in epidermal growth factor (EGF; MIM 131530)-like repeats orthrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is anO-fucosyltransferase that use THBS type-1 repeats as substrates(Luo et al., 2006 [PubMed 16464857]).
Feng, T., et al. Hum. Genet. 128(3):269-280(2010)Luo, Y., et al. J. Biol. Chem. 281(14):9385-9392(2006)Luo, Y., et al. J. Biol. Chem. 281(14):9393-9399(2006)Menzel, O., et al. Genomics 84(2):320-330(2004)Martinez-Duncker, I., et al. Glycobiology 13 (12), 1C-5C (2003) :
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