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PVRL3 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NQS3
Clone Names 100405244
Peptide ID 100405244
Additional Information
Gene ID 25945
Other Names Nectin-3, CDw113, Poliovirus receptor-related protein 3, CD113, PVRL3, PRR3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NECTIN3 (HGNC:17664)
Synonyms PRR3, PVRL3
Function Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis- mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Cellular Location Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane
Tissue Location Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines
Research Areas
Citations (0)

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Background

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-likeadhesion molecules that interact with afadin (AF6; MIM 159559).Afadin is an actin filament-binding protein that connects nectinsto the actin cytoskeleton. The nectin-afadin system organizesadherens junctions cooperatively with the cadherin (see MIM192090)-catenin (see MIM 116805) system in epithelialcells.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Yu, X., et al. Nat. Immunol. 10(1):48-57(2009)Fujito, T., et al. J. Cell Biol. 171(1):165-173(2005)

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$ 80.00
Cat# BP12866b
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