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CREM Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession Q03060
Other Accession Q03061, P27699, Q1LZH5, NP_874390.1, NP_874391.1, NP_874388.1, NP_874389.1, NP_853549.1, NP_874387.1, NP_874386.1
Additional Information
Gene ID 1390
Other Names cAMP-responsive element modulator, Inducible cAMP early repressor, ICER, CREM
Target/Specificity The synthetic peptide sequence is selected from aa 109-122 of HUMAN CREM
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
Cellular Location Nucleus.
Tissue Location Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes
Research Areas
Citations (0)

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This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.


Wu, H., et al. FEBS Lett. 584(13):2807-2815(2010)
Pierard, V., et al. J. Biol. Chem. 285(25):19434-19449(2010)
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Chakraborty, K., et al. J. Biol. Chem. 284(33):21810-21827(2009)

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$ 80.00
$ 99.00
Cat# BP12891c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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