|Other Names||Corticotropin-releasing factor-binding protein, CRF-BP, CRF-binding protein, Corticotropin-releasing hormone-binding protein, CRH-BP, CRHBP, CRFBP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|
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Provided below are standard protocols that you may find useful for product applications.
Corticotropin-releasing hormone is a potent stimulator ofsynthesis and secretion of preopiomelanocortin-derived peptides.Although CRH concentrations in the human peripheral circulation arenormally low, they increase throughout pregnancy and fall rapidlyafter parturition. Maternal plasma CRH probably originates from theplacenta. Human plasma contains a CRH-binding protein whichinactivates CRH and which may prevent inappropriatepituitary-adrenal stimulation in pregnancy.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Holliday, K.L., et al. J Psychosom Res 68(5):469-474(2010)Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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