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CRHBP Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P24387 |
|---|---|
| Clone Names | 81006052 |
| Gene ID | 1393 |
|---|---|
| Other Names | Corticotropin-releasing factor-binding protein, CRF-BP, CRF-binding protein, Corticotropin-releasing hormone-binding protein, CRH-BP, CRHBP, CRFBP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CRHBP |
|---|---|
| Synonyms | CRFBP |
| Function | Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Corticotropin-releasing hormone is a potent stimulator ofsynthesis and secretion of preopiomelanocortin-derived peptides.Although CRH concentrations in the human peripheral circulation arenormally low, they increase throughout pregnancy and fall rapidlyafter parturition. Maternal plasma CRH probably originates from theplacenta. Human plasma contains a CRH-binding protein whichinactivates CRH and which may prevent inappropriatepituitary-adrenal stimulation in pregnancy.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Holliday, K.L., et al. J Psychosom Res 68(5):469-474(2010)Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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