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DCTN2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13561 |
|---|---|
| Clone Names | 81006075 |
| Gene ID | 10540 |
|---|---|
| Other Names | Dynactin subunit 2, 50 kDa dynein-associated polypeptide, Dynactin complex 50 kDa subunit, DCTN-50, p50 dynamitin, DCTN2, DCTN50 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DCTN2 (HGNC:2712) |
|---|---|
| Synonyms | DCTN50 |
| Function | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A5G2QD80} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a 50-kD subunit of dynactin, amacromolecular complex consisting of 10-11 subunits ranging in sizefrom 22 to 150 kD. Dynactin binds to both microtubules andcytoplasmic dynein. It is involved in a diverse array of cellularfunctions, including ER-to-Golgi transport, the centripetalmovement of lysosomes and endosomes, spindle formation, chromosomemovement, nuclear positioning, and axonogenesis. This subunit ispresent in 4-5 copies per dynactin molecule. It contains threeshort alpha-helical coiled-coil domains that may mediateassociation with self or other dynactin subunits. It may interactdirectly with the largest subunit (p150) of dynactin and may affixp150 in place.
References
Jacquot, G., et al. J. Biol. Chem. 285(30):23019-23031(2010)Inoue, M., et al. Genes Cells 13(8):905-914(2008)Maier, K.C., et al. Traffic 9(4):481-491(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Camargo, L.M., et al. Mol. Psychiatry 12(1):74-86(2007)
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