GCAT Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75600 |
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Clone Names | 81020112 |
Gene ID | 23464 |
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Other Names | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, AKB ligase, Aminoacetone synthase, Glycine acetyltransferase, GCAT, KBL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GCAT (HGNC:4188) |
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Synonyms | KBL |
Function | Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA. |
Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:Q0P5L8}. Nucleus. Note=Translocates to the nucleus upon cold and osmotic stress. |
Tissue Location | Strongly expressed in heart, brain, liver and pancreas. Also found in lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The degradation of L-threonine to glycine consists of atwo-step biochemical pathway involving the enzymes L-threoninedehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase.L-Threonine is first converted into 2-amino-3-ketobutyrate byL-threonine dehydrogenase. This gene encodes the second enzyme inthis pathway, which then catalyzes the reaction between2-amino-3-ketobutyrate and coenzyme A to form glycine andacetyl-CoA. The encoded enzyme is considered a class IIpyridoxal-phosphate-dependent aminotransferase. Alternate splicingresults in multiple transcript variants. A pseudogene of this geneis found on chromosome 14.
References
Jacquot, C., et al. Anticancer Res. 22(4):2229-2235(2002)Edgar, A.J., et al. Eur. J. Biochem. 267(6):1805-1812(2000)Tressel, T., et al. J. Biol. Chem. 261(35):16428-16437(1986)
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