|Other Names||2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, AKB ligase, Aminoacetone synthase, Glycine acetyltransferase, GCAT, KBL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion. Nucleus. Note=Translocates to the nucleus upon cold and osmotic stress|
|Tissue Location||Strongly expressed in heart, brain, liver and pancreas. Also found in lung.|
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Provided below are standard protocols that you may find useful for product applications.
The degradation of L-threonine to glycine consists of atwo-step biochemical pathway involving the enzymes L-threoninedehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase.L-Threonine is first converted into 2-amino-3-ketobutyrate byL-threonine dehydrogenase. This gene encodes the second enzyme inthis pathway, which then catalyzes the reaction between2-amino-3-ketobutyrate and coenzyme A to form glycine andacetyl-CoA. The encoded enzyme is considered a class IIpyridoxal-phosphate-dependent aminotransferase. Alternate splicingresults in multiple transcript variants. A pseudogene of this geneis found on chromosome 14.
Jacquot, C., et al. Anticancer Res. 22(4):2229-2235(2002)Edgar, A.J., et al. Eur. J. Biochem. 267(6):1805-1812(2000)Tressel, T., et al. J. Biol. Chem. 261(35):16428-16437(1986)
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