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GCAT Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O75600
Clone Names 81020112
Additional Information
Gene ID 23464
Other Names 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, AKB ligase, Aminoacetone synthase, Glycine acetyltransferase, GCAT, KBL
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GCAT (HGNC:4188)
Synonyms KBL
Function Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA.
Cellular Location Mitochondrion {ECO:0000250|UniProtKB:Q0P5L8}. Nucleus. Note=Translocates to the nucleus upon cold and osmotic stress.
Tissue Location Strongly expressed in heart, brain, liver and pancreas. Also found in lung.
Research Areas
Citations (0)
citation

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Background

The degradation of L-threonine to glycine consists of atwo-step biochemical pathway involving the enzymes L-threoninedehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase.L-Threonine is first converted into 2-amino-3-ketobutyrate byL-threonine dehydrogenase. This gene encodes the second enzyme inthis pathway, which then catalyzes the reaction between2-amino-3-ketobutyrate and coenzyme A to form glycine andacetyl-CoA. The encoded enzyme is considered a class IIpyridoxal-phosphate-dependent aminotransferase. Alternate splicingresults in multiple transcript variants. A pseudogene of this geneis found on chromosome 14.

References

Jacquot, C., et al. Anticancer Res. 22(4):2229-2235(2002)Edgar, A.J., et al. Eur. J. Biochem. 267(6):1805-1812(2000)Tressel, T., et al. J. Biol. Chem. 261(35):16428-16437(1986)

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$ 277.78
Cat# BP12897a
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