|Other Names||Lactoylglutathione lyase, Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase, GLO1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
The enzyme encoded by this gene is responsible for thecatalysis and formation of S-lactoyl-glutathione from methylglyoxalcondensation and reduced glutatione. Glyoxalase I is linked to HLAand is localized to 6p21.3-p21.1, between HLA and the centromere.
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Naidu, R., et al. Pathol. Int. 60(9):614-620(2010)Santarius, T., et al. Genes Chromosomes Cancer 49(8):711-725(2010)Kovanen, L., et al. Alcohol Alcohol. 45(4):303-311(2010)Krechler, T., et al. Clin. Biochem. 43 (10-11), 882-886 (2010) :
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