|Other Names||Glutathione S-transferase theta-1, GST class-theta-1, Glutathione transferase T1-1, GSTT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.|
|Tissue Location||Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles|
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Provided below are standard protocols that you may find useful for product applications.
Glutathione S-transferase (GST) theta 1 (GSTT1) is amember of a superfamily of proteins that catalyze the conjugationof reduced glutathione to a variety of electrophilic andhydrophobic compounds. Human GSTs can be divided into five mainclasses: alpha, mu, pi, theta, and zeta. The theta class includesGSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequenceidentity and both of them were claimed to have an important role inhuman carcinogenesis. The GSTT1 gene is located approximately 50kbaway from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similarstructure, being composed of five exons with identical exon/intronboundaries.
Palli, D., et al. Mutagenesis 25(6):569-575(2010)Henderson, A.J., et al. Thorax 65(10):897-902(2010)Filonzi, L., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):743-747(2010)Smith, G., et al. Pharmacogenet. Genomics (2010) In press :Bid, H.K., et al. J Postgrad Med 56(3):176-181(2010)
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